Polynucleotide Skin Rejuvenation

Polynucleotides for skin rejuvenation is a professional aesthetic treatment carried out at artethic® in Düsseldorf by experienced specialist physicians. In a personal consultation, we will explain all the details of the treatment to you.

The duration of treatment varies depending on the scope and individual requirements. We will advise you of the estimated duration during your personal consultation.

The cost of polynucleotide skin rejuvenation is determined individually following a personal consultation. The price depends on the extent of treatment and your individual wishes. We are happy to provide you with a no-obligation quote.

You can book a consultation by telephone on +49 211 87598360 or via our online contact form. The initial consultation is entirely without obligation, and we allow ample time for all your questions.

Our specialist physicians inject these in gel form directly into the skin. The treatment is performed using very fine cannulas and is considered exceptionally gentle. If required, a light anaesthetic cream can be applied a few minutes before the treatment – you will then barely feel the injections. Over the days and weeks – and up to several months – following treatment, polynucleotides continuously improve skin elasticity, hydration and overall skin quality. The skin gradually becomes firmer and more vital as a result of fibroblast growth and enhanced collagen production.

Yes. The results of a treatment with biostimulants such as polynucleotides are generally long-lasting. Since natural skin ageing continues nonetheless and the skin is subject to a wide range of daily environmental and lifestyle stresses, we recommend regular maintenance treatments.

Almost all of our patients resume their normal activities immediately after the treatment, whether personal or professional. Any redness around the injection sites can generally be concealed easily with make-up. We recommend a specialist eye mask, which you will receive from us after your treatment. You can also purchase this for use over the following days at our practice.

At the practice of Dr. Karl Schuhmann and colleagues (Artethic Medical Aesthetics) in Düsseldorf, we use polynucleotides on the face, around the eyes, on the neck and décolletage, on the hands, and in all areas where lasting skin rejuvenation and revitalisation is desired. Another major area of application is the treatment of fine hair and hair loss. Unlike conventional fillers, the injection of polynucleotides under the eyes carries no long-term complications, as the active substance does not burden the fatty tissue with excessive fluid retention.

The results are a consequence of the accelerated natural regeneration of the skin. It produces increased amounts of collagen and elastin – a process that requires some time. The effect therefore develops gradually. Here is an overview: Directly after treatment, the skin immediately appears plumper and firmer following the injection. It is now well hydrated. This effect diminishes slightly over the following days. Minor redness is possible, which subsides within a few days. To accelerate this, we recommend Arnica D6 (globules) or bromelain (pineapple enzymes). First visible improvements after 2 to 4 weeks: the first regenerative effect of the polynucleotides becomes apparent. The skin feels firmer, appears smoother and gains in resilience and elasticity. Fine lines may already be reduced. After the 2nd treatment (at 8 weeks), the 3×3 formula applies: ideally, you will require three treatments spaced three weeks apart. Maximum effect after 8 to 12 weeks: approximately six months to a year after the treatment, the full effect of the polynucleotides has developed. New collagen fibres have formed, and the complexion appears fresher, more youthful and more radiant.

Typical side effects include skin redness and, in some cases, a slightly raised, whealed appearance around the eyes. We recommend an eye mask for continued care at home. You will also receive this mask directly after your treatment – so that you are socially presentable again by the following day at the latest. To minimise side effects, we recommend enzymes such as Arnica D6. Take these three to four days before the injection. You can obtain these homoeopathic remedies from your pharmacy.

We charge (as of March 2025) €450 per individual treatment – for a course of 3 × 3 sessions.

Almost all of our patients resume their normal activities – whether personal or professional – immediately after treatment. Any redness around the injection sites can usually be easily concealed with make-up. We recommend a specialist eye mask, which you will receive from us following the treatment. You can also purchase this for the days ahead at our practice.

The results emerge as a consequence of the accelerated natural regeneration of the skin. The skin produces increased amounts of collagen and elastin – a process that takes some time. The effects therefore develop gradually. Here is an overview:
Directly after treatment
Immediately after the injection, the skin initially appears plumper and firmer. It is now well hydrated. This effect diminishes slightly over the following days. Minor redness is possible, which subsides within a few days. To accelerate this, we recommend Arnica D6 (globules) or bromelain (pineapple enzymes).
First visible improvements after 2 to 4 weeks
The first regenerative effect of the
polynucleotides
now becomes apparent. The skin feels firmer, appears smoother and gains in resilience and elasticity. Fine lines may already be reduced.
After the 2nd treatment (at 8 weeks), the 3×3 formula applies: ideally, you will require three treatments spaced three weeks apart.
Maximum effect after 8 to 12 weeks
Approximately six months to a year after the treatment, the full effect of the
polynucleotides
has developed. New collagen fibres have formed, and the complexion appears fresher, more youthful and more radiant.